Jett's Case Profile - Vidium Animal Health

Jett’s Case Profile

Jett is a 12-year-old male neutered Golden Retriever who was noted to have a large ulcerated mass along the left buccal mucosa during an annual exam. The mass was surgically removed and was histologically identified as a poorly differentiated sarcoma, although malignant melanoma was also suspected. It was also noted to have high mitotic activity (14/10 HPF).

Jett, a handsome Golden Retriever, had an incidentally found intra-oral mass that was histologically identified as a poorly differentiated sarcoma, although malignant melanoma was also suspected.
A SearchLight DNA test revealed multiple alterations, with the amplification of CDK4 and MDM2 supporting the diagnosis of melanoma. The CDK4 amplification suggested sensitivity to palbociclib, and an ATM deletion suggested sensitivity to olaparib.
In Jett’s case, SearchLight DNA supported the diagnosis of melanoma and additionally provided therapeutic options based on published biomarker associations.