SearchLight DNA® Guides Cancer Diagnosis and Treatment Decisions: Jett
Jett, a handsome golden retriever, had an incidentally found intra-oral mass that was histologically identified as a poorly differentiated sarcoma, although malignant melanoma was also suspected.
A SearchLight DNA test revealed multiple alterations, with the amplification of CDK4 and MDM2 supporting the diagnosis of melanoma. The CDK4 amplification suggested sensitivity to palbociclib, and an ATM deletion suggested sensitivity to olaparib.
In Jett’s case, SearchLight DNA supported the diagnosis of melanoma and additionally provided therapeutic options based on published biomarker associations.
A 10-year-old golden retriever named Nira was diagnosed with histiocytic sarcoma. After completing an initial course of radiation therapy, medical treatment with cobimetinib was started based on literature suggesting the tumor could bear KRAS and PTPN11 mutations, which are associated with response to cobimetinib.
A SearchLight DNA test revealed the absence of KRAS or PTPN11 mutations along with the presence of a mutation that suggested cobimetinib resistance. The treatment plan was switched to only radiation therapy and sirolimus.
In Nira’s case, SearchLight DNA provided valuable data that informed her treatment plan.