SearchLight DNA™ for veterinarians

Knowing a tumor’s genetic fingerprint can aid in the diagnosis and prognosis of cancer and inform treatment decisions. SearchLight DNA is an extensively validated, next-generation diagnostic test that identifies important mutations in 120 relevant cancer genes. The most informative canine cancer genetic test available, it incorporates all high-quality diagnostic, prognostic, and predictive biomarkers known from canine and human cancer studies into a proprietary knowledge database.

As a “pan-cancer” precision diagnostic, prognostic, and therapeutic indicator, SearchLight DNA uses a targeted Next-Generation Sequencing (NGS) gene panel to identify point mutations, copy number mutations, and internal tandem duplications in 120 known cancer genes, as well as the chemo-sensitivity gene MDR1. It is appropriate for fine-needle aspirates (FNA), formalin-fixed, paraffin-embedded (FFPE) tissue, or fresh frozen tumor samples.

To learn more about how SearchLight DNA was validated view the poster from the Veterinary Cancer Society Conference

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What does SearchLight DNA do?

By finding mutations in the DNA of your patient’s cancer cells, Vidium’s SearchLight DNA can help guide your veterinary team in understanding a cancer’s origin, its behavior, and the optimal approach to its treatment.

Many cancers are recognizable to the trained pathologists and oncologists who diagnose and treat them.

But not all cancers. Sometimes the mutations in a cancer can guide diagnosis, which is a key part of understanding what that tumor will do in the body. Some mutations only occur in specific cancer types or sub-types and so they can aid the veterinary team in identifying the cancer types.

Diagnosis

Many mutations have been associated with a better or worse prognosis.

Thinking about the future and what comes next may be the scariest aspect of cancer. Knowing as much as we can about a cancer’s potential behavior is critically important for guiding pet families and veterinarians as they work together to generate the very best plan for that particular cancer in that particular patient and that specific family.

Tabs Aids

The whole point of understanding cancer is understanding how to stop it.

In human oncology, hundreds of safe and effective “precision therapies” exist that are directed against a cancer’s specific mutations. Fewer precision therapies exist in veterinary medicine, but as we better understand therapeutic targets in pet cancers, we believe that these therapies will become increasingly available. In some cases, we can use human drugs that are available today.

Tabs Identifies Targets

How does SearchLight DNA work?

At Vidium, we partner with your pathologists to gain as much information about your patient’s tumor as possible.

Our scientists extract the DNA from your patient’s tumor sample, check it for quality and quantity, sequence the DNA in our state-of-the-art Next-Generation Sequencing (NGS) laboratory, and then analyze (each individual cancer genome) to identify its unique mutations.

We then use our proprietary biomarker database, Vidium Insight, to bring the very latest information on mutation-based diagnostic, prognostic, and treatment guidance to each case.

By using the latest in genomic science, we can learn more about what is driving a tumor and provide valuable, clinically applicable information not available by traditional diagnostic tests.

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Cancer Patient
Pet with suspected cancer visits the veterinarian.

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Veterinary Team
The veterinary team performs a biopsy to collect a sample of the tumor. The sample is sent to Vidium or is sent to a pathologist and then sent to Vidium.

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Vidium Animal Health
Vidium performs tumor DNA sequencing and analysis with SearchLight DNA, annotating the tumor mutations with biomarker data from its knowledge database.

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Reports
Vidium provides a detailed report to the veterinary team with information about the tumor’s mutations and their associations with diagnosis, prognosis, and treatment.

What does the report reveal?

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The most relevant mutations
in the tumor’s DNA

Using next-generation sequencing of 120 cancer-associated genes selected based on the latest scientific literature and databases, SearchLight DNA provides the clinical team and pet family with the confidence that if a clinically relevant mutation is present, we’ve found it. These mutations can inform diagnosis, prognosis, and treatment planning.

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Easily understandable summaries of
what we know about these mutations

Vidium scientists have assembled all of the latest published data in human and veterinary studies to provide the most up-to-date knowledge database possible. We deliver that information to the healthcare team in a digestible, but complete and well-referenced format.

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Targeted therapies

Using data from veterinary and human oncology, SearchLight DNA provides information on therapies that may be indicated by mutations in a pet’s tumor. It also provides a summary of the scientific evidence associated with those indications.

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Clinical trials

Leveraging the AVMA’s Clinical Trials Database along with a supplemental curation of trials at academic centers and through industry partners, Vidium provides the healthcare team with up-to-date information on additional options for pets with cancer.

SearchLight DNA can be used

as part of the diagnostic workup of any cancer case to acquire more diagnostic, prognostic and therapeutic information. SearchLight DNA is particularly useful for the following:
Inconclusive histology or cytology report
Unexpected cancer behavior
Uncommon site for tumor type
Presumptive diagnosis
Unclear treatment course
Interest in exploring novel therapies