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Publications

Publications & Scientific Presentations

View the clinical evidence supporting the use of Vidium’s diagnostic tests.

Scientific Presentations

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Presentation by Dr. Esther Chon at the American College of Veterinary Medicine Conference 2022

Tumor Genomic Analysis for Diagnostically Challenging Cancer Cases

Explore the clinical utility of genomics in diagnostically challenging oncology cases. Genomic Analysis with SearchLight DNA® can provide valuable diagnostic, prognostic and therapeutic information in over 80% of these cases. (33 minutes)

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Presentation by Dr. Guannan Wang at the American College of Veterinary Medicine Conference 2022

Standing in the Canine Precision Medicine Knowledge Gap: Improving Annotation of Canine Cancer Genomic Biomarkers through Systematic Comparative Analysis of Human Cancer Mutations in COSMIC

Learn how Vidium Animal Health is leveraging human cancer data to improve annotation of canine cancer mutation data and close the knowledge gap that is essential to enable canine cancer precision medicine. (19 minutes)

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Presentation by Dr. Guannan Wang at the Veterinary Cancer Society Annual Conference; 2021

A Survey of Canine Cancer Genomic Biomarkers Based on Structured Literature Review, Meta-Analysis, and Comparative Genomics

This presentation shows how Vidium Animal Health constructed a canine cancer genomic biomarker database through systematic review, meta-analysis and harmonization of cancer mutation data from canine and human sources. (15 minutes)

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Publications

Javma
Genomic tumor analysis provides clinical guidance for the management of diagnostically challenging cancers in dogs; 2023

Esther Chon DVM, DACVIM, Guannan Wang PhD, et. al.

This study evaluated a genomic test – SearchLight DNA™ – that is the first of its kind in veterinary medicine by providing diagnostic guidance, prognostic information, and therapeutic options, all in one report. The findings supports SearchLight DNA™ as a guide for veterinarians in managing diagnostically challenging cancers in dogs.

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Example 4
Poster presentation at the Veterinary Cancer Society 2022 Annual Conference; 2022

Chon E, Adkins J, Duran N, et al. Mutation Landscape and Clinical Actionability in Canine Melanoma

This conference poster presentation details how SearchLight DNA™ can be used to identify biomarkers with diagnostic, prognostic, and therapeutic associations for canine melanoma.

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Example 4
Poster presentation at the Veterinary Cancer Society 2022 Annual Conference; 2022

Warrier M, Wong S, Sakthikumar S, et al. Development and Validation Procedures for Improving SearchLight DNA™, a Canine Cancer Genomic Diagnostic Panel

This conference poster presentation details our validation process for SearchLight DNA™.

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Example 4
Poster presentation at the Veterinary Cancer Society 2020 Annual Conference; 2020

Wong S, Warrier M, Byron S, et al. Design, analytical validation and diagnostic yield of a novel canine cancer gene sequencing panel.
This conference poster presentation details the validation process for SearchLight DNA.

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Additional genomic and veterinary health publications

The following is a list of publications that have been authored by our team members on various topics in genomics and veterinary medicine

Genomics in Canine Oncology

Identification of Genetic Susceptibility Factors Associated with Canine Gastric Dilatation-Volvulus
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Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma
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Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2
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Polymerase chain reaction for antigen receptor rearrangement: Benchmarking performance of a lymphoid clonality assay in diverse canine sample types.
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Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis
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Precision medicine: an opportunity for a paradigm shift in veterinary medicine
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Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.
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Actionable mutations in canine hemangiosarcoma
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Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma
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Canine Oncopanel: a capture-based, NGS platform for evaluating the mutational landscape and detecting driver mutations in canine cancers
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Genomics in Human Medicine

PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer
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Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT)
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Rapid Sequencing-Based Diagnosis of Thiamine Metabolism Dysfunction Syndrome
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Whole genome bisulfite sequencing of cell-free DNA and its cellular contributors uncovers placenta hypomethylated domains
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High-throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma
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Immune epitope database analysis resource
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Immune epitope database analysis resource (IEDB-AR)
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Veterinary Medicine

Veterinarians and shelter animals
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Population characteristics of golden retriever lifetime study enrollees
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The Golden Retriever Lifetime Study: establishing an observational cohort study with translational relevance for human health
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Incremental cholesterol reduction with ezetimibe/simvastatin, atorvastatin and rosuvastatin in UK General Practice (IN-PRACTICE): randomised controlled trial of achievement of Joint British Societies (JBS-2) cholesterol targets
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Support for network to advance veterinary medical research
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Cyclophosphamide rescue therapy for relapsed low-grade alimentary lymphoma after chlorambucil treatment in cats
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Clinical effects of vinorelbine administration in the management of various malignant tumor types in dogs: 58 cases (1997-2012)
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Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs
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Activation of the canonical Wnt/β-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines
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Safety evaluation of combination toceranib phosphate (Palladia®) and piroxicam in tumour-bearing dogs (excluding mast cell tumours): a phase I dose-finding study
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1)
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Mitotic Figures-Normal, Atypical, and Imposters: A Guide to Identification
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Oestrogen responsive vulvovaginal lipoma in an intact Siberian Husky
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International Guidelines for Veterinary Tumor Pathology: A Call to Action.
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