View the clinical evidence supporting the use of Vidium’s diagnostic tests.
Tumor Genomic Analysis for Diagnostically Challenging Cancer Cases
Explore the clinical utility of genomics in diagnostically challenging oncology cases. Genomic Analysis with SearchLight DNA® can provide valuable diagnostic, prognostic and therapeutic information in over 80% of these cases. (33 minutes)
Standing in the Canine Precision Medicine Knowledge Gap: Improving Annotation of Canine Cancer Genomic Biomarkers through Systematic Comparative Analysis of Human Cancer Mutations in COSMIC
Learn how Vidium Animal Health is leveraging human cancer data to improve annotation of canine cancer mutation data and close the knowledge gap that is essential to enable canine cancer precision medicine. (19 minutes)
A Survey of Canine Cancer Genomic Biomarkers Based on Structured Literature Review, Meta-Analysis, and Comparative Genomics
This presentation shows how Vidium Animal Health constructed a canine cancer genomic biomarker database through systematic review, meta-analysis and harmonization of cancer mutation data from canine and human sources. (15 minutes)
Sakthikumar S, Warrier M, Whitley D, et al.
In a retrospective investigation of 828 canine cases across 53 cancer types analysed by SearchLight DNATM, we identified mutation profiles and evaluated clinical actionability in both pan-cancer and tumour-type-specific settings.
Esther Chon, DVM, Sharadha Sakthikumar, et al. Novel genomic prognostic biomarkers for dogs with cancer
Growing evidence from dogs and humans supports the abundance of mutation-based biomarkers in tumors of dogs. Increasing the use of clinical genomic diagnostic testing now provides another powerful data source for biomarker discovery.
Esther Chon, DVM, Jon Adkins, et al. Novel genomic prognostic biomarkers for canine cancer patients
This conference poster presentation details how SearchLight DNA™ was used to successfully direct clinicians to therapies that increased their patients’ progression-free survival outcomes.
Sharadha Sakthikumar, PhD, Derick Whitley, DVM, et al. Genomic analysis across 50 canine cancer types reveals novel mutations and putative high clinical actionability
This conference poster presentation details how SearchLight DNA™ was used to identify mutation-based diagnostic, prognostic, and therapeutic biomarkers — ultimately allowing clinicians to successfully manage their patients’ cancer.
Sharadha Sakthikumar, PhD, Salvatore Facista, et al. Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC
Advancements in canine oncology depend on utilizing human mutation data. This study presents a structured analysis of sequence conservation and conversion of human mutations to the canine genome through a ‘caninisation’ process.
Dr. David Haworth authored these featured articles in the Fountain Report – a weekly newsletter covering animal health business news, insights, and educational services. Learn how innovation in biotechnology benefits veterinary medicine.
Esther Chon DVM, DACVIM, Guannan Wang PhD, et. al.
This study evaluated a genomic test – SearchLight DNA™ – that is the first of its kind in veterinary medicine by providing diagnostic guidance, prognostic information, and therapeutic options, all in one report. The findings supports SearchLight DNA™ as a guide for veterinarians in managing diagnostically challenging cancers in dogs.
Chon E, Adkins J, Duran N, et al. Mutation Landscape and Clinical Actionability in Canine Melanoma
This conference poster presentation details how SearchLight DNA™ can be used to identify biomarkers with diagnostic, prognostic, and therapeutic associations for canine melanoma.
Warrier M, Wong S, Sakthikumar S, et al. Development and Validation Procedures for Improving SearchLight DNA™, a Canine Cancer Genomic Diagnostic Panel
This conference poster presentation details our validation process for SearchLight DNA™.
Wong S, Warrier M, Byron S, et al. Design, analytical validation and diagnostic yield of a novel canine cancer gene sequencing panel.
This conference poster presentation details the validation process for SearchLight DNA.
The following is a list of publications that have been authored by our team members on various topics in genomics and veterinary medicine
Genomics in Canine Oncology
Genomics in Human Medicine