Case Profile

Genomic case profile

The following is a genomic case profile highlighting how SearchLight DNA™ was used to guide treatment planning:
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  • A 10-year-old Golden Retriever was diagnosed with histiocytic sarcoma. After completing an initial course of radiation therapy, medical treatment with cobimetinib was started based on literature suggesting the tumor could bear KRAS and PTPN11 mutations, which are associated with response to cobimetinib.
  • A SearchLight DNA test revealed the absence of KRAS or PTPN11 mutations along with the presence of a mutation that suggested cobimetinib resistance. The treatment plan was switched to only radiation therapy and sirolimus.
  • In Nira’s case, SearchLight DNA provided valuable data that informed her treatment plan.