This 50-minute course covers precision medicine and its clinical applicability to veterinary oncology. We will explore innovation in cancer medicine, the definition of “precision medicine,” the role genomics plays in human oncology diagnosis and treatment planning, and the progression of genomic data and utility in veterinary oncology. The clinical relevance of genomic mutations in canine cancer will be discussed. Examples of the growing role of cancer genomic diagnostics in veterinary oncology will be analyzed through real-world examples.